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Effect of surfaces and osmolytes in modulating peptide assembly

Joan-Emma Shea

Intrinsically disordered peptides are a special class of proteins that do not fold to a unique three-dimensional shape. These proteins play important roles in the cell, from signaling to serving as structural scaffolds. Under pathological conditions, these proteins are capable of self-assembling into structures that are toxic to the cell, and a number of neurodegenerative diseases, such as Alzheimer’s disease and Parkinson’s disease, are associated with this self-assembly process. In this talk, I will discuss the effect of surfaces and the osmolytes urea and TMAO in regulating the structure and assembly of intrinsically disordered peptides. I will focus on two model systems, the mussel foot protein implicated in underwater adhesion of mussels to rocks, and the Tau peptide implicated in Alzheimer’s Disease.

Speaker: Joan-Emma Shea, UC Santa Barbara

Tuesday, 01/29/19

Contact:

Website: Click to Visit

Cost:

Free

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Latimer Hall

UC Berkeley
Room 120
Berkeley, CA 94720