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3D Human Brain Models and Nanoplatforms for Prognostics and Therapeutics of Neurological Disorders

Alzheimer’s disease (AD) is the most common cause of dementia. However, no definitive cure for AD exists due to lack of limited model systems that accurately reflect AD-related immunity in human brains, nor for a drug development strategy for delivery across the blood-brain barrier (BBB) and assessment of drug efficacy in human brains.

Here, I present micro-scaled 3D environments that reconstruct AD human brain tissue and a BBB as the test platforms mimicking AD pathology. I also demonstrate nanobiosensors utilizing aptamers and surface plasmonics for the purpose of monitoring the brain's activities with high sensitivity, specificity, and stability.

Furthermore, I present preliminary results on a bio-conjugated-cPOSS-MSN nanoplatform to achieve multitargeting and multivalence effect in a central nervous system.

Speaker: Hansang Cho, Univ. of North Carolina, Charlotte

Friday, 04/12/19


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LeConte Hall, Rm 4

UC Berkeley
Berkeley, CA 94720