Alzheimer’s disease (AD) is the most common cause of dementia. However, no definitive cure for AD exists due to lack of limited model systems that accurately reflect AD-related immunity in human brains, nor for a drug development strategy for delivery across the blood-brain barrier (BBB) and assessment of drug efficacy in human brains.
Here, I present micro-scaled 3D environments that reconstruct AD human brain tissue and a BBB as the test platforms mimicking AD pathology. I also demonstrate nanobiosensors utilizing aptamers and surface plasmonics for the purpose of monitoring the brain's activities with high sensitivity, specificity, and stability.
Furthermore, I present preliminary results on a bio-conjugated-cPOSS-MSN nanoplatform to achieve multitargeting and multivalence effect in a central nervous system.
Speaker: Hansang Cho, Univ. of North Carolina, Charlotte
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