In eukaryotes, DNA replication origins are activated in the late G1 phase of cell cycle, in which Origin Recognition Complex recruits the helicase core Mcm2-7 onto DNA and assemble an inactive double-hexamer. The Mcm2-7 double-hexamer is converted to two active CMG (Cdc45-Mcm2-7-GINS) helicases at the G1-to-S transition. And in the S phase, the CMG helicases works with DNA polymerases, primases and numerous additional protein factors to synthesize DNA. In my talk, I will describe molecular insights we have obtained by cryo-EM imaging of several protein complexes involved in the DNA replication process.
Speaker: Huilin Li, Van Andel Research Institute
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