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Deep Mutagenesis of a DNA Polymerase Clamp-Loader System

Clamp loaders are AAA+ ATPases that load sliding clamps onto DNA. We have developed a high-throughput platform for mutagenesis of components of the DNA replication system of T4 bacteriophage, and are using it to understand allosteric coupling in the component proteins.

Speaker: John Kuriyan, UC Berkeley

Monday, 08/30/21


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Stanley Hall

UC Berkeley
Room 105
Berkeley, CA 94720