A Raman-Based Endoscopic Strategy For Multiplexed Molecular Imaging

A novel, opto-electro-mechanical Raman endoscope that has the potential to significantly improve the detection and diagnosis of certain early-stage cancers and inflammatory diseases has been developed. This is a platform technology, which utilizes a panel of targeting surface-enhanced Raman scattering (SERS) nanoparticles, each with a uniquely detectable spectral fingerprint, in conjunction with a custom-built Raman fiber-optic device that can be used in combination with any endoscope or laparoscope. The aim is to provide the benefits of real-time diagnostic information during endoscopy or laparoscopy by employing molecular specificity that builds on the white-light imaging that is provided by today's technology.

Speaker: Ellis Garai, Stanford