Modulation of cancer-specific interactomes via chemical switches and molecular glues

Chemically induced proximity of bimolecular complexes is a powerful modality to rewire signal transduction networks. Most extensively studied in the context of protein degradation, the full scope and potential of chemically induced proximity for novel targets and pharmacological mechanisms has yet to be realized. I will discuss structure-based strategies to advance chemically induced proximity in several complementary areas, including as an approach to overcome drug resistance and as a mechanism to achieve ultra-selective modulators of kinase targets.

Speaker: Arvin Dar, Memorial Sloan Kettering Cancer Center