New concepts in high-speed bio-imaging: from bench top to clinic

Current approach in diagnosis of biological samples mainly relies on histopathology of tissue or blood cells, where the samples are processed, chemically-stained, and inspected under a light microscope. This approach is not only inherently invasive and time consuming, but also costly, impractical for a large population of samples and dangerous for some organs. High-throughput imaging technologies provide an alternative pathway to overcome these challenges and ultimately deliver better health care solutions. This presentation introduces new approaches based on time-encoded single-pixel cameras, enabling a number of microscopy methods such as ultrafast Nomarski microscopy and time-encoded full-field high-resolution imaging. It also discusses the principles and latest progress towards clinical translation of a high-speed imaging technology, integrating optical coherence tomography and near-infrared spectroscopy for simultaneous microstructural and compositional assessment of coronary artery disease in living patients.

Speaker: Ali Aard, Harvard Medical School