Illuminating the Biochemical Activity Architecture of the Cell

The complexity and specificity of cellular processes require spatial microcompartmentation and dynamic modulation of the underlying biochemical activities, such as dynamic phosphorylation and dephosphorylation catalyzed by specific protein kinases and phosphatases, respectively. We hypothesize that cellular biochemical activities are spatially organized into an “activity architecture” and reorganization and restructuring of this activity architecture lead to disease. In this talk, I will present the development and application of a series of fluorescent biosensors that we have developed to monitor biochemical events in living cells.

Speaker: Jin Zhang, UC San Diego