Quantifying the physical genome

My lab aims to understand how a 2 meter long object, the human genome, encodes for molecules which, through physical interaction with the genome itself, evince the immense cellular diversity we observe in the human body. I will discuss efforts to catalog regulatory elements and transcription factor grammars that are advice during human fetal development, and describe single molecule approaches for quantitatively understanding the relationship between transcription factor binding sites, transcription factor occupancy, and gene expression in human cells.

Speaker: William Greenleaf, Stanford University