The long and the short of it: Mechanistic insights into the mRNA poly(A) tail machinery

Cells are defined by the genes they express. Moreover, rapid changes in gene expression allow cells to respond to their environments. The Passmore lab uses biochemical reconstitution, structural biology and functional studies to gain mechanistic insights into mRNA processing, mRNA stability and genome integrity - fundamental processes that affect gene expression in all eukaryotes. This lecture will explore how poly(A) tails are added and removed from mRNAs. More specifically, how are the enzymes that modulate poly(A) tails co-ordinated and co-regulated with each other and with transcription and translation to modulate gene expression?

Speaker: Lori Passmore, MRC Laboratory of Molecular Biology