Chemical methods to monitor and manipulate the proteome

The development of potent probe molecules and drug leads for proteins that lack deep pockets remains an important and difficult problem. This seminar will focus on methods being developed in the Kodadek Laboratory to address this problem. Topics to be discussed will include the development of “beyond rule of 5” macrocycles to engage difficult targets, screening strategies that will allow the facile discovery of molecular glues and the development of Ubiquitin-independent protein degraders.