Microfluidics in Next Gen Proteomics

While the genomics revolution has had sweeping impact on our understanding of life processes, the "proteomics revolution" still remains unrealized.  Proteins are more directly linked to function than genes, but proteins are also dynamic and more biochemically complex. Consequently, protein analysis often demands multi-stage biochemical assays to measure not one, but multiple physicochemical properties.  At UC Berkeley, we are introducing novel non-discretizing integration strategies to answer this problem. This talk will highlight multi-stage assays uniquely enabled by our 'µMosaic' fabrication technique:  an approach that allows regional photopatterning of 2D microchambers with heterogeneous, discrete nanomaterials.  In one example, I will summarize our recent progress towards fast, hands-free, and perhaps even quantitative Western blotting, for analysis of specimens from clinical sample repositories. Our ultimate goal is to understand the life processes – including development and disease through quantitative bioinstrumentation.

Speaker: Amy E. Herr, Ph.D., UC Berkeley

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