Seeing and Engineering Biomolecular Condensates with Atomic PrecisionPhase separation of RNA-binding proteins via multivalent interactions between aromatic/polar-rich disordered domains contributes to the formation of functional cytoplasmic granules and nuclear puncta. These domains have also been identified as players in cancer-causing fusion proteins as well as the nucleators of neuronal inclusions in amyotrophic lateral sclerosis (ALS), frontotemporal dementia, ...
