In this presentation, several chemical and biocatalytic syntheses of amino acid-derived natural products will be discussed. Ribosomally synthesized and post-translationally modified peptides (RiPPs) are a growing class of natural products, many of which possess antimicrobial activity. Sactipeptides are one subclass of RiPPs that are defined by thioaminoketal functional groups. In ...
Building and controlling new chemical matter is the foundational challenge in chemistry and the confluence of two tools, nonequilibrium control and machine learning, is providing exciting opportunities to expand our capabilities for control. In this talk, I will describe two efforts that sit at the interface between chemistry and machine ...
