Molecular Glues: From Mechanisms to TherapeuticsMolecular glue (MG) degraders represent an exciting new modality in drug discovery highlighted by their ability to degrade undruggable targets and their favorable pharmacological properties. Thus far, only a very small number of MG degraders have been serendipitously found, most of which act on CULLIN4 E3 ubiquitin ligases. The scarcity ...
The second dimension of the genetic codeDNA stores genetic information in the sequence of the four canonical bases dA, dC, dG, and T and, in addition, carries epigenetic information encoded by the four modified cytidine bases: 5-methylcytidine (mdC), 5-hydroxymethylcytidine (hmdC), 5-formylcytidine (fdC), and 5-carboxycytidine (cadC), with 5-hydroxymethyluridine (hmdU) potentially playing a role as well. These additional ...
