Computational Approaches for Understanding and Engineering Biomolecular Condensates

The interior of cells contains numerous components that must be carefully organized in space to fulfill a wide range of biological functions. The most common form of intracellular compartment does not have membranes. Instead of membranes, these compartments, known as biomolecular condensates, are maintained and spatially segregated through phase separation.

Understanding biomolecular condensates is crucial, as they play significant roles in both health and disease, and present novel opportunities for bioengineering and materials design. In addition to experiments, molecular modeling and simulations have emerged as powerful tools, offering us the detailed perspectives needed to elucidate the physicochemical principles governing the properties of biomolecular condensates.

In this talk, I will discuss our current efforts to develop quantitatively accurate computational models for understanding and engineering biomolecular condensates, especially within the context of intracellular phase separation.

Speaker: Jerelle Joseph, Princeton University

Room: 3108