Mechanisms and importance of lysosome repair

Damaged lysosomes are harmful to cells and participate in propagation of neurotoxic protein aggregates. Recent studies have shown that damaged lysosomes can be repaired by several alternative mechanisms. In our group we have been characterizing lysosome repair mediated by ESCRT proteins and lipids transferred from the endoplasmic reticulum. In my presentation I will discuss our recent findings regarding possible cooperations between these mechanisms and the molecular machinery of lysophagy - autophagic degradation of damaged lysosomes.

Speaker: Harold Stenmark, Oslo University