Structure and Function of Mammalian SWI/SNF Chromatin Remodeling Complexes in Health and Disease

ATP-dependent chromatin remodeling complexes are heterogeneous, multi-component molecular machines that govern genomic accessibility and gene expression and are frequently perturbed in human disease. This presentation highlights biochemical and structural advances that have enabled the mechanistic understanding of mSWI/SNF complex activities and functional assignment of mSWI/SNF-transcription factor interactions in developmental and disease states, opening new opportunities for targeted intervention.

Speaker: Cigall Kadoch, Harvard Medical School