De novo design of RNA with deep learning

RNA design has long been limited by the accuracy of RNA structure prediction. I will describe how the video game Eterna has elicited modeling and design tools for previously intractable pseudoknotted folds, multi-state sensors for disease states, and polymerase ribozymes that copy RNA. AI teams now work alongside Eterna players, and both are scored by prospective high-throughput experiments. Under that pressure, RNA design is improving quickly.

Speaker: Rhiju Das, Stanford University