Bystander T cell activation: an immunologic double-edged swordMemory CD8 T cells are conventionally called to arms by TCR recognition of cognate antigen; however, inflammation alone can elicit T cell cytotoxicity in the absence of cognate antigen. The consequences of this phenomenon, termed bystander activation, can range from beneficial (pathogen clearance) to deleterious (autoimmune pathology), yet the mechanisms ...
