Bystander T cell activation: an immunologic double-edged swordMemory CD8 T cells are conventionally called to arms by TCR recognition of cognate antigen; however, inflammation alone can elicit T cell cytotoxicity in the absence of cognate antigen. The consequences of this phenomenon, termed bystander activation, can range from beneficial (pathogen clearance) to deleterious (autoimmune pathology), yet the mechanisms ...
Where: BerkeleyCost: Free
Thursday, 02/27/25
Rules, Regulations, and Randomness: From Biological to Social SystemsAcross both biological and social systems, rules and regulations play a crucial role in ensuring robustness and resistance to fluctuations across diverse environments. The expansion of rule systems over time is particularly relevant in contemporary political discourse, where some argue that society is over-regulated and that bureaucratic structures should be ...
Where: BerkeleyCost: Free
Friday, 02/28/25
Signal (re)processing: How disease states shape signal transduction in CD8+ T cellsPersistent antigen signaling is known to drive CD8+ T cell exhaustion (TEX) in cancer and chronic infection, but which downstream kinase cascades control this process are unknown. We found that activation of protein kinase C (PKC) triggers degradation of PKC theta while sparing PKC eta, leading to terminal TEX cells. In chronic ...
