Rules, Regulations, and Randomness: From Biological to Social SystemsAcross both biological and social systems, rules and regulations play a crucial role in ensuring robustness and resistance to fluctuations across diverse environments. The expansion of rule systems over time is particularly relevant in contemporary political discourse, where some argue that society is over-regulated and that bureaucratic structures should be ...
Where: BerkeleyCost: Free
Friday, 02/28/25
Signal (re)processing: How disease states shape signal transduction in CD8+ T cellsPersistent antigen signaling is known to drive CD8+ T cell exhaustion (TEX) in cancer and chronic infection, but which downstream kinase cascades control this process are unknown. We found that activation of protein kinase C (PKC) triggers degradation of PKC theta while sparing PKC eta, leading to terminal TEX cells. In chronic ...
Where: BerkeleyCost: Free
Tuesday, 03/04/25
Intracellular lipid transport in immunoregulation and metabolismAnimal cells are essentially assemblies of membrane compartments marked by diversity and asymmetry of lipids. There remains a significant gap in understanding the biological processes and purposes of lipid localization and trafficking in specialized cell types. Immune cells, with their remarkable adaptability to evolving threats and ability to migrate to ...
